Cyprodime hydrochloride_product_DataBase

Bioactivity	Cyprodime hydrochloride is a highly selective μ-opioid receptor antagonist with Ki values of 5.4 nM, 244.6 nM and 2187 nM for μ-, δ- and κ-opioid receptors, respectively. Cyprodime hydrochloride has anti-depressant-like effect[1][2].
Target	Ki: 5.4 nM (μ-opioid), 244.6 nM (δ-opioid) and 2187 nM (κ-opioid)
Invitro	Cyprodime hydrochloride has Ki values of 8.1 nM and 26.6 nM for μ-opioid receptor in rat brain (Wistar) and guinea pig brain[1].
In Vivo	Cyprodime hydrochloride (3, 10 mg/kg; i.p.; 60 min prior to test) significantly increases immobility time in the forced swimming test (FST) with higher dose of 10 mg/kg. Cyprodime hydrochloride increases the grooming time[2]. Animal Model:
Name	Cyprodime hydrochloride
CAS	2387505-50-0
Formula	C22H30ClNO3
Molar Mass	391.93
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Márki A, et al. Mu-opioid receptor specific antagonist cyprodime: characterization by in vitro radioligand and [35S]GTPgammaS binding assays. Eur J Pharmacol. 1999 Oct 27;383(2):209-14. [2]. Haj-Mirzaian A, et al. Involvement of opioid system in behavioral despair induced by social isolation stress in mice. Biomed Pharmacother. 2019 Jan;109:938-944.

PeptideDB