| Bioactivity | AZD5213 is a selective and competitive human H3 receptor antagonist with a pKi value of 9.3 for hH3R. AZD5213 can be used for the research of sleep and cognitive regulation[1][2]. |
| In Vivo | AZD5213 (1 mg/kg；静脉注射一次) 迅速减少 [11C] 4-(1S,2S)-2-(4-cyclobutylpiperazine-1-carbonyl)-cyclopropyl]-N-methyl-benzamide 与小鼠大脑所有区域的结合[1]。 |
| Name | AZD5213 |
| CAS | 1119807-02-1 |
| Formula | C19H25N3O2 |
| Molar Mass | 327.42 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Schou M, et al. Discovery and Preclinical Validation of [(11)C]AZ13153556, a Novel Probe for the Histamine Type 3 Receptor. ACS Chem Neurosci. 2016 Feb 17;7(2):177-84. [2]. Nikolic K, et al. Procognitive properties of drugs with single and multitargeting H3 receptor antagonist activities. CNS Neurosci Ther. 2014 Jul;20(7):613-23. |