| Bioactivity | CypD-IN-4 is a potent and subtype-selective cyclophilin D (CypD) inhibitor. CypD-IN-4 has CypD affinity with an IC50 value of 0.057 μM. CypD-IN-4 can be used for the research of several diseases including oxidative stress, neurodegenerative disorders, liver diseases, aging, autophagy and diabetes[1]. |
| Target | IC50: 0.057 μM (CypD); 3.4 μM (CypA); 1.1 μM (CypB); 0.8μM (CypE) |
| Invitro | CypD-IN-4 (B53) has selectivity for inhibiting CypD, CypA, CypB and CypE with IC50 values of 0.057 μM, 3.4 μM, 1.1 μM and 0.8 μM, respectively[1].CypD-IN-4 (20 μM) inhibits mitochondrial permeability transition pore opening in isolated mitochondria[1]. |
| Name | CypD-IN-4 |
| Formula | C54H63N7O11 |
| Molar Mass | 986.12 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Alexander A Peterson, et al. Discovery and molecular basis of subtype-selective cyclophilin inhibitors. Nat Chem Biol. 2022 Sep 26. |