| Bioactivity | Cyclosporin A-Derivative 1 (Free base) is a crystalline intermediate derived from the opening of cyclosporin A extracted from patent WO 2013167703 A1. Cyclosporin A is an immunosuppressive agent which can bind to the cyclophilin and inhibit calcineurin. | ||||||
| Invitro | Cyclosporin A-Derivative 1 is a non-immunosuppressive Cyclosporin A derivative. The cyclosporin is acylated on the butenyl-methyl-threonine side chain and then subjected to a ring-opening reaction (the ring opens between the sarcosine and the N-methyl-leucine residues). Cyclosporin A-Derivative 1 is a linear peptide intermediate[1]. | ||||||
| Name | Cyclosporin A-Derivative 1 Free base | ||||||
| CAS | 286852-20-8 | ||||||
| Sequence | Leu-Val-Leu-Ala-{d-Ala}-Leu-Leu-Val-{Aaa}-{Abu}-{Sar} | ||||||
| Shortening | LVLA-{d-Ala}-LLV-{Aaa}-{Abu}-{Sar} | ||||||
| Formula | C65H117N11O14 | ||||||
| Molar Mass | 1276.69 | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
Cyclosporin A-Derivative 1 Free base
CAS: 286852-20-8 F: C65H117N11O14 W: 1276.69
Cyclosporin A-Derivative 1 (Free base) is a crystalline intermediate derived from the opening of cyclosporin A extracted
Data collection：peptidedb@qq.com
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