| Bioactivity | Cyclorasin 9A5 TFA is an 11-residue cell-permeable cyclic peptide that orthosterically inhibits the Ras-Raf protein interaction with an IC50 of 120 nM[1]. | ||||||
| Target | IC50: 120 nM (Ras-Raf protein interaction). | ||||||
| Sequence | Cyclo({d-Ala}-Arg-Arg-Arg-{d-Nal}-Arg-{4F-Phe}-{d-Nle}-Gln-Trp-Thr) | ||||||
| Shortening | Cyclo({d-Ala}-RRR-{d-Nal}-R-{4F-Phe}-{d-Nle}-QWT) | ||||||
| Formula | C75H108FN25O13.xC2HF3O2 | ||||||
| Molar Mass | 1586.82 (free base) | ||||||
| Appearance | 固体 | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
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| Reference | [1]. Koh Takeuchi, et al. Conformational Plasticity of Cyclic Ras-Inhibitor Peptides Defines Cell Permeabilization Activity. Angew Chem Int Ed Engl. 2021 Mar 15;60(12):6567-6572. |
Cyclorasin 9A5 TFA
CAS: F: C75H108FN25O13.xC2HF3O2 W: 1586.82 (free base)
Cyclorasin 9A5 TFA is an 11-residue cell-permeable cyclic peptide that orthosterically inhibits the Ras-Raf protein inte
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