Cyclobenzaprine N-oxide_product_DataBase

Bioactivity	Cyclobenzaprine N-oxide is the tertiary amine metabolite of Cyclobenzaprine (HY-B0740) in liver particles. Cyclobenzaprine is a skeletal muscle relaxant and is active on the central nervous system. The liver cytosol from liver particles has reductase activity that can reduce Cyclobenzaprine N-oxide to the corresponding amine[1][2][3].
Name	Cyclobenzaprine N-oxide
CAS	6682-26-4
Formula	C20H21NO
Molar Mass	291.39
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Kitamura S, et al. Reduction of tertiary amine N-oxides by liver preparations: function of aldehyde oxidase as a major N-oxide reductase. Biochem Biophys Res Commun. 1984 Jun 29;121(3):749-54. [2]. Kobayashi, et al. Ono, Cyclobenzaprine, a centrally acting muscle relaxant, acts on descending serotonergic systems. Eur J Pharmacol, 1996. 311(1): p. 29-35. [3]. Belvedere G, et al. Identification of cyclobenzaprine-10, 11-epoxide and other metabolites after incubation of cyclobenzaprine with rat liver microsomes[J]. Xenobiotica, 1975, 5(12): 765-771.

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