| Bioactivity | Cyclin K degrader 1 (compound 40) is an AT7519 (HY-50940) based Cyclin K degrader with DC50 of 21 nM[1]. |
| Invitro | Cyclin K degrader 1（1 μM, 2 h）在有 DDB-1 参与的情况下降解 Cyclin K[1]。Cyclin K degrader 1（1 μM, 2 h）能够降解 99 ± 1 % Cyclin K，DC50值是 21 nM, Dmax >95%， CDK12 Kd值为 1000 nM[1]。 0 --> Cyclin K degrader 1 相关抗体: |
| Name | Cyclin K degrader 1 |
| Formula | C23H17Cl2N5O2 |
| Molar Mass | 466.32 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Thomas KL, et al., Degradation by Design: New Cyclin K Degraders from Old CDK Inhibitors. ACS Chem Biol. 2024 Jan 19;19(1):173-184. doi: 10.1021/acschembio.3c00616 |