| Bioactivity | Custirsen sodium is a highly specific antisense oligonucleotide that inhibits the production of clusterin , an antiapoptotic protein that is upregulated in response to chemotherapy and that confers treatment resistance. |
| Formula | C231H292N78Na20O119P20S20 |
| Molar Mass | 7786.00 |
| Appearance | 固体 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | -20°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
| Reference | [1]. Chi KN, Eisenhauer E, Fazli L, et al. A phase I pharmacokinetic and pharmacodynamic study of OGX-011, a 2'-methoxyethyl antisense oligonucleotide to clusterin, in patients with localized prostate cancer. J Natl Cancer Inst. 2005;97(17):1287-1296. |
Custirsen sodium
CAS: F: C231H292N78Na20O119P20S20 W: 7786.00
Custirsen sodium is a highly specific antisense oligonucleotide that inhibits the production of clusterin , an antiapopt
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