| Bioactivity | Cot inhibitor-1 (compound 28) is a selective tumor progression loci-2 (Tpl2) kinase inhibitor with an IC50 of 28 nM. Cot inhibitor-1 shows an inhibition of TNF-alpha production in human whole blood with an IC50 of 5.7 nM[1]. | ||||||||||||
| Target | IC50: 28 nM (Tpl2 kinase) | ||||||||||||
| Name | Cot inhibitor-1 | ||||||||||||
| CAS | 915365-57-0 | ||||||||||||
| Formula | C27H27Cl2FN8 | ||||||||||||
| Molar Mass | 553.46 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Junjun Wu, et al. Selective inhibitors of tumor progression loci-2 (Tpl2) kinase with potent inhibition of TNF-alpha production in human whole blood. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3485-8. |
Cot inhibitor-1
CAS: 915365-57-0 F: C27H27Cl2FN8 W: 553.46
Cot inhibitor-1 (compound 28) is a selective tumor progression loci-2 (Tpl2) kinase inhibitor with an IC50 of 28 nM. Cot
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