| Bioactivity | Corilagin, a gallotannin, has anti-tumor, anti-inflammatory and hepatoprotective activities. Corilagin inhibits activity of reverse transcriptase of RNA tumor viruses. Corilagin also inhibits the growth of Staphylococcus aureus with a MIC of 25 μg/mL. Corilagin shows anti-tumor activity on hepatocellular carcinoma and ovarian cancer model. Corilagin shows low toxicity to normal cells and tissues[1][2][3]. | ||||||||||||
| Invitro | Corilagin (0-50 μM, 24 h) 抑制 SGC7901 和 BGC823 细胞生长, 且细胞变圆[2]。Corilagin (0-30 μM, 24 h) 诱导 SGC7901 和 BGC823 细胞凋亡[2]。Corilagin (0-30 μM，24 小时) 降低 SGC7901 和 BGC823 细胞中 procaspase-8、-9 和 -3 的蛋白水平并增加裂解的 PARP[2]。Corilagin (0-30 μM, 24 h) 在 SGC7901 和 BGC823 细胞中诱导自噬 (酸性囊泡增强，LC3II 水平升高)[2].Corilagin (0-30 μM, 24 h) 诱导 SGC7901 和 BGC823 细胞产生 ROS[2]。Corilagin (40 μM，24 或 48 小时) 在 Hey 和 SKOv3ip 细胞中诱导 G2 细胞周期停滞和细胞凋亡[3]。Corilagin (0-80 μM，1-3 天) 抑制 Hey、SKOv3ip 和 HO8910PM 细胞中 TGF-β1 的分泌[3]。 Cell Viability Assay[2] Cell Line: | ||||||||||||
| Name | Corilagin | ||||||||||||
| CAS | 23094-69-1 | ||||||||||||
| Formula | C27H22O18 | ||||||||||||
| Molar Mass | 634.45 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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