| Bioactivity | Clofoctol is a bacteriostatic antibiotic. Clofoctol is used in the treatment of respiratory tract and ear, nose and throat infections caused by Gram-positive bacteria. Clofoctol is only functional against Gram-positive bacteria and can penetrate into human lung tissue. Clofoctol is also an inhibitor of prostate cancer. Clofoctol has antiviral potency[1][2][3]. | ||||||||||||
| Invitro | Clofoctol (0-100 μM; 72 h) inhibits prostate cancer cell growth[2].Clofoctol (0-20 μM; 24 h) arrests cell cycle at G1 phase[2].Clofoctol (0-30 μM; 0-24 h) induces ER stress and activates UPR pathways[2].Clofoctol (0-40 μM; 24 h) inhibits translation[2].Clofoctol (0-100 μM; 24 h) shows antiviral effect against SARS-CoV-2 with IC50s of 9.3 μM and 11.59 μM in Vero-81 and Vero-81-TMPRSS2 cells, respectively[3]. Cell Viability Assay[2] Cell Line: | ||||||||||||
| Name | Clofoctol | ||||||||||||
| CAS | 37693-01-9 | ||||||||||||
| Formula | C21H26Cl2O | ||||||||||||
| Molar Mass | 365.34 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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