| Bioactivity | Compstatin TFA, a 13-residue cyclic peptide, is a potent inhibitor of the complement system C3 with species specificity. Compstatin TFA binds to baboon C3 and is resistant to proteolytic cleavage in baboon blood (similar to humans). Compstatin TFA inhibits only the activation of primates’ complement system. Compstatin TFA exhibits IC50 values of 63 μM and 12 μM for classical and alterative complement pathway, respectively[1][2][3]. | ||||||
| Invitro | Compstatin exhibits an in vitro half-life in human blood of about 2 hr[2].In solution, compstatin forms a β-turn at residues Gln-5–Gly-8 with the disulfide bridge Cys-2–Cys12, residues Ile-1–Val-4, and Thr-13, forming a hydrophobic cluster[3]. | ||||||
| Name | Compstatin TFA | ||||||
| Shortening | ICVVQDWGHHRCT-NH2 (Disulfide bridge: Cys2-Cys12) | ||||||
| Formula | C68H100F3N23O19S2 | ||||||
| Molar Mass | 1664.79 | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture and light
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |
Compstatin TFA
CAS: F: C68H100F3N23O19S2 W: 1664.79
Compstatin TFA, a 13-residue cyclic peptide, is a potent inhibitor of the complement system C3 with species specificity.
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