| Bioactivity | Cobimetinib-13C6 (GDC-0973-13C6; XL518-13C6) racemateis the deuterium labeledCobimetinib (racemate)(HY-13078)[1]. Cobimetinib racemate (GDC-0973 racemate; XL518 racemate) is the racemate of Cobimetinib. Cobimetinib is a potent and selective MEK inhibitor[2]. |
| Invitro | 氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱[1]。 |
| Name | Cobimetinib-13C6 racemate |
| Formula | C1513C6H21F3IN3O2 |
| Molar Mass | 537.27 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. |
Cobimetinib-13C6 racemate
CAS: F: C1513C6H21F3IN3O2 W: 537.27
Cobimetinib-13C6 (GDC-0973-13C6; XL518-13C6) racemateis the deuterium labeledCobimetinib (racemate)(HY-13078). Cobimetin
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