| Bioactivity | CYT296 is a target chromatin de-condensation compound. CYT296 can improve the induction of induced pluripotent stem cell (iPSCs) mediated by defined factors (OSKM) and induce an open chromatin state in Mouse Embryonic Fibroblast (MEFs) to facilitate somatic cell reprogramming. CYT296 can be used for cell replacement therapies and drug screening research[1]. | ||||||||||||
| Invitro | CYT296 (250nM, 72小时) 改变 MEFs 染色质，使 Yamanaka 因子更容易接近，并促进重编程过程[1]。CYT296 (250nM, 72小时) 小分子阻断 MEFs 中异染色质组装可以显著改善 iPSC 的生成[1]。 Immunofluorescence[1] Cell Line: | ||||||||||||
| In Vivo | CYT296 (10-15 4F- and 2F -iPSC clones, 皮下注射, 一次) 在 NOD-SCID 小鼠中生成的 iPSCs 具有多能性[1]。 Animal Model: | ||||||||||||
| Name | CYT296 | ||||||||||||
| CAS | 1799392-31-6 | ||||||||||||
| Formula | C18H16O2S | ||||||||||||
| Molar Mass | 296.38 | ||||||||||||
| Appearance | Oil | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Wei X, et al. Small molecule compound induces chromatin de-condensation and facilitates induced pluripotent stem cell generation. J Mol Cell Biol. 2014 Oct;6(5):409-20. |