| Bioactivity | Co 101244 (PD 174494) hydrochloride is a NR2B-containing NMDA receptor antagonist[1]. |
| Invitro | Co 101244 effectively reduces NMDA-evoked Ca2+ elevations while enhancing neuroprotection[1]. |
| In Vivo | Co 101244 (0.1, 1 mg/kg s.c.) displayed antidyskinetic effects (67 and 71% reduction, respectively) while sparing levodopa motor benefit[1]. |
| Name | Co 101244 hydrochloride |
| CAS | 193356-17-1 |
| Formula | C21H28ClNO3 |
| Molar Mass | 377.90 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
| Reference | [1]. Ruslan I Stanika, et al. Coupling diverse routes of calcium entry to mitochondrial dysfunction and glutamate excitotoxicity. Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9854-9. |