Bupropion morpholinol_product_DataBase

Bioactivity	Bupropion morpholinol (Hydroxy Bupropion) is a major metabolite of Bupropion. Bupropion morpholinol inhibits Dopamine, Norepinephrine transporters and the α4β2 nicotinic receptor in vitro. Bupropion morpholinol contributes to antidepressant and smoking cessation activities[1][2][3].
Target	Dopamine transporter, Norepinephrine transporter, α4β2 nicotinic receptor
Invitro	Bupropion morpholinol is produced from Bupropion by the genetically polymorphic enzyme CYP2B6 in vivo[1].Bupropion morpholinol inhibits [3H]norepinephrine uptake with an IC50 of 1.7 μM[2].
Name	Bupropion morpholinol
CAS	357399-43-0
Formula	C13H18ClNO2
Molar Mass	255.74
Appearance	Solid
Transport	Room temperature in continental US; may vary elsewhere.
Storage	-20°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Reference	[1]. Zhu AZX, et, al. CYP2B6 and bupropion's smoking-cessation pharmacology: the role of hydroxybupropion. Clin Pharmacol Ther. 2012 Dec;92(6):771-7. [2]. Damaj MI, et, al. Enantioselective effects of hydroxy metabolites of bupropion on behavior and on function of monoamine transporters and nicotinic receptors. Mol Pharmacol. 2004 Sep;66(3):675-82. [3]. Damaj MI, et, al. Effects of hydroxymetabolites of bupropion on nicotine dependence behavior in mice. J Pharmacol Exp Ther. 2010 Sep 1;334(3):1087-95.

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