| Bioactivity | Cholicamideβ (compound 6) is a self-assembling, small molecule, cancer vaccine adjuvant. Cholicamideβ can form virus-like particles with low cytotoxicity. Cholicamideβ, upon binding to peptide antigens, enhances antigen presentation by dendritic cells and induces antigen-specific T cells. Cholicamideβ can induce apoptosis and necrosis[1]. |
| Invitro | Cholicamideβ (compound 6) (4-16 μM; 22 h) 在 RAW264.7 细胞中诱导凋亡和坏死[1]。 0 --> Cholicamideβ 相关抗体: |
| In Vivo | Cholicamideβ (compound 6) (100 μg/mouse; 16 h 和 21 d 后检测) 在经由流感裂解疫苗免疫过的 C57BL/6 小鼠中表现出低毒性，增加 HA 特异性 IgG 抗体滴度[1]。 |
| Name | Cholicamideβ |
| Formula | C55H94N2O6 |
| Molar Mass | 879.34 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zhuo SH, et al. Identification of a Self-Assembling Small-Molecule Cancer Vaccine Adjuvant with an Improved Toxicity Profile. J Med Chem. 2023 Sep 7.. . |