| Bioactivity | Cholesteryl hemisuccinate is a with hepatoprotective an anticancer activity. Cholesteryl hemisuccinate inhibits Acetaminophen (AAP, HY-66005) hepatotoxicity, and prevents AAP-induced hepatic apoptosis and necrosis. Cholesteryl hemisuccinate inhibits DNA polymerase and DNA topoisomerase to inhibit DNA replication and repair and cell division. Thus, Cholesteryl hemisuccinate inhibits tumor growth[1][2]. | ||||||||||||
| In Vivo | Cholesteryl hemisuccinate（100 mg/kg；ip；AAP 前单次给药）消除 AAP（350-500 mg/kg；ip；单次给药）在 ICR 小鼠 (CD-1) 中诱导的细胞凋亡和坏死的组织学和生化诊断[1]。 | ||||||||||||
| Name | Cholesteryl hemisuccinate | ||||||||||||
| CAS | 1510-21-0 | ||||||||||||
| Formula | C31H50O4 | ||||||||||||
| Molar Mass | 486.73 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Ray SD, et al. Protection of acetaminophen-induced hepatocellular apoptosis and necrosis by cholesteryl hemisuccinate pretreatment. J Pharmacol Exp Ther. 1996 Dec;279(3):1470-83. [2]. Varshosaz J, et al. Folated synperonic-cholesteryl hemisuccinate polymeric micelles for the targeted delivery of docetaxel in melanoma. Biomed Res Int. 2015;2015:746093. |
Cholesteryl hemisuccinate
CAS: 1510-21-0 F: C31H50O4 W: 486.73
Cholesteryl hemisuccinate is a with hepatoprotective an anticancer activity. Cholesteryl hemisuccinate inhibits Acetamin
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