| Bioactivity | Axinelline A is a potent COX inhibitor with IC50s of 2.22 μM and 8.89 μM against COX-2 and COX-1, respectively. Axinelline A shows anti-inflammatory activity[1]. |
| Invitro | Axinelline A (2-30 μM; 24 h) 抑制脂多糖 (LPS; HY-D1056) 诱导的 RAW264.7 细胞中促炎因子 (NO、TNF-α、IL-6、IL-1β 和 PGE2) 的表达[1]。Axinelline A (2-30 μM; 24 h) 抑制 LPS 诱导的 RAW264.7 细胞 NF-κB 信号通路[1]。 Western Blot Analysis[1] Cell Line: |
| Name | Axinelline A |
| CAS | 1593741-99-1 |
| Formula | C12H15NO6 |
| Molar Mass | 269.25 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ju Z, et al. Synthesis and Anti-Inflammatory Activity of the Natural Cyclooxygenase-2 Inhibitor Axinelline A and Its Analogues. J Nat Prod. 2023 Apr 28;86(4):958-965. |
Axinelline A
CAS: 1593741-99-1 F: C12H15NO6 W: 269.25
Axinelline A is a potent COX inhibitor with IC50s of 2.22 μM and 8.89 μM against COX-2 and COX-1, respectively. Axinel
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