| Bioactivity | Chitinase-IN-4 (compound 8f), an azo-aminopyrimidine derivative, is a potent, selective OfChi-h inhibitor with an IC50 value of 0.1 μM. Chitinase-IN-4 has good insecticidal activity. Chitinase-IN-4 can be used in research of green pest control and management[1]. |
| Invitro | Chitinase-IN-4 (compound 8f; 0-1 μM) displays outstanding inhibitory potency via a benzyl on the amino group at the 4-position of pyrimidine, exhibits a Ki value of 64.7 nM against OfChi-h[1].Chitinase-IN-4 (100-500 μg/mL; 48 h) has insecticidal activity. Chitinase-IN-4 displays 100% mortality against P. xylostella at a concentration of 500 μg/mL, which is much higher than that of the control drug hexaflumuron, and inhibits 22.5% Ostrinia nubilalis at a concentration of 500 μg/mL[1]. |
| Name | Chitinase-IN-4 |
| Formula | C21H24ClN7 |
| Molar Mass | 409.92 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Dong L, et, al. Discovery of Azo-Aminopyrimidines as Novel and Potent Chitinase OfChi-h Inhibitors via Structure-Based Virtual Screening and Rational Lead Optimization. J Agric Food Chem. 2022 Sep 19. |