| Bioactivity | Chitin synthase inhibitor 12 is a chitin synthase inhibitor. Chitin synthase inhibitor 12 shows excellent inhibitory activity with an IC50 value of 0.16 mM. Chitin synthase inhibitor 12 also is a broad-spectrum antifungal agent and has significantly antifungal activity against drug-resistant fungal variants, such as C. albicans and C. neoformans. Chitin synthase inhibitor 12 can be used for the research of invasive fungal infections (IFIs)[1]. |
| Target | IC50: 0.16 mM (chitin synthase)MIC: 64 μg/mL (C. albicans); 16 μg/mL (A. flavus); 64 μg/mL (A. fumigatus); 64 μg/mL (C. neoformans) |
| Invitro | Chitin synthase inhibitor 12 (compound 9t) (300 ug/mL) has good inhibitory activity against chitin synthase with an IC50 value of 0.16 mM[1].Chitin synthase inhibitor 12 has antifungal activity for C. albicans, A. flavus, A. fumigatus and C. neoformans with MIC values of 64 μg/mL, 16 μg/mL, 64 μg/mL and 64 μg/mL, respectively[1].Chitin synthase inhibitor 12 has broad-spectrum antifungal activity in vitro and has additive or synergistic effects combined with fluconazole[1].Chitin synthase inhibitor 12 is related to the disruption of cell wall architecture[1]. |
| Name | Chitin synthase inhibitor 12 |
| Formula | C23H21ClFN3O5 |
| Molar Mass | 473.88 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Yajie Xu, et al. Spiro[benzoxazine-piperidin]-one derivatives as chitin synthase inhibitors and antifungal agents: Design, synthesis and biological evaluation. Eur J Med Chem. 2022 Aug 31;243:114723 |
Chitin synthase inhibitor 12
CAS: F: C23H21ClFN3O5 W: 473.88
Chitin synthase inhibitor 12 is a chitin synthase inhibitor. Chitin synthase inhibitor 12 shows excellent inhibitory act
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