CWI1-2 hydrochloride_product_DataBase

Bioactivity	CWI1-2 hydrochloride is an IGF2BP2 inhibitor that binds IGF2BP2 and inhibits its interaction with m6A-modified target transcripts, induces apoptosis and differentiation, and shows promising anti-leukemic effects[1].
Invitro	CWI1-2 (0-1 μM, 24 h) hydrochloride 具有良好的抗白血病功效[1]。 Apoptosis Analysis[1] Cell Line:
In Vivo	CWI1-2（5 mg/kg，i.v.，每日一次，7-10天）hydrochloride 可显着延缓 BMT 受体 B6.SJL（CD45.1）小鼠白血病的发生和存活时间，体重无明显影响 [1]。
Name	CWI1-2 hydrochloride
CAS	2408590-37-2
Formula	C22H18Cl4N6O3
Molar Mass	556.23
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Hengyou Weng, et al. The m6A reader IGF2BP2 regulates glutamine metabolism and represents a therapeutic target in acute myeloid leukemia. Cancer Cell. 2022 Dec 12;40(12):1566-1582.e10.

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