| Bioactivity | CVN636 is a potent, orally active and selective mGluR7 allosteric agonist with an EC50 value of 7 nM for hu mGluR7. CVN636 has central nervous system (CNS) permeability[1]. |
| In Vivo | CVN636 (0.3-3 mg/kg; p.o.) 减少 msP 大鼠的乙醇自我给药[1]。 Animal Model: |
| Name | CVN636 |
| CAS | 2226732-62-1 |
| Formula | C19H20FNO4S |
| Molar Mass | 377.43 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ayscough AP, et, al. Discovery of CVN636: A Highly Potent, Selective, and CNS Penetrant mGluR7 Allosteric Agonist. ACS Med Chem Lett. 2023 Mar 2;14(4):442-449. [2]. Dickson L, et, al. Discovery of CVN636: A Highly Potent, Selective, and CNS Penetrant mGluR7 Allosteric Agonist. ACS Med Chem Lett. 2023 Mar 2;14(4):442-449. |