| Bioactivity | CSF1R-IN-21 (compound 7e) is a CSF-1R Inhibitor with an IC50 value of 31 nM. CSF1R-IN-21 inhibits CSF-1R auto-phosphorylation and can be used for the research of neurodegenerative diseases [1]. |
| Invitro | CSF1R-IN-21 (compound 7e) (10 μM, 6 h) 可抑制 CSF-1R 自磷酸化，并在 EOC 20 细胞系的细胞活力测定中显示出较低的细胞毒性[1]。CSF1R-IN-21 (50 μM, 4 h) 在平行人工膜透性试验 (PAMPA) 中表现出较好的血脑屏障通透性[1]。 CSF1R-IN-21 (10 M, 0/30/120 min) 在血浆稳定性测试中表现良好[1]。CSF1R-IN-21 (1 mM, 30 min) 在微粒体稳定性测试中表现出中等稳定性[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> CSF1R-IN-21 相关抗体: Cell Viability Assay[1] Cell Line: |
| CAS | 2935479-62-0 |
| Formula | C24H20F3N5O3 |
| Molar Mass | 483.44 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Baek J, et al. Discovery of N-(5-amido-2-methylphenyl)-5-methylisoxazole-3-carboxamide as dual CSF-1R/c-Kit Inhibitors with improved stability and BBB permeability. Eur J Med Chem. 2024 Feb 20;268:116253. |