CS17919_product_DataBase

Bioactivity	CS17919 is a potent, selective and orally active ASK1 inhibitor with an IC50 of 22.52 nM. CS17919 shows anti-inflammatory and antifibrotic effects. CS17919 can be used for the study of metabolic-related kidney and liver diseases[1].
Invitro	CS17919 (0.32-10 μM；72 小时) 为棕榈酸处理的 LO2 细胞提供有效保护[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> CS17919 相关抗体: Apoptosis Analysis[1] Cell Line:
In Vivo	CS17919（10-60 mg/kg；口服；每日两次；持续 11 天）可改善 UUO 模型中的肾损伤和纤维化[1]。CS17919（50 mg/kg；口服；每日两次；持续 70 天）可缓解 DKD 模型中的肾小球硬化[1]。CS17919（20 mg/kg；口服；每日两次；持续 4 周）可改善 NASH 模型中的肝脏炎症和纤维化[1]。口服后 CS17919 在 C57BL/6J 中的药代动力学参数[1]。 1.19 Parameters
CAS	2379346-41-3
Formula	C22H20F4N6O2
Molar Mass	476.43
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Guoqiang Liao, et al. Targeting ASK1 by CS17919 alleviates kidney- and liver-related diseases in murine models. Animal Model Exp Med. 2024 Jun 14.

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