CP 122721 hydrochloride_product_DataBase

CAS: 145877-52-7 F: C20H25Cl2F3N2O2 W: 453.33

CP 122721 hydrochloride is a potent, non-peptide and selective nonpeptide neurokinin NK1 antagonist, with a pIC50 of 9.8

This product is for research use only, not for human use. We do not sell to patients.

Bioactivity	CP 122721 hydrochloride is a potent, non-peptide and selective nonpeptide neurokinin NK1 antagonist, with a pIC50 of 9.8 for human NK1 receptor expressed in IM-9 cells. CP 122721 hydrochloride exhibits anxiolytic and antidepressant-like effects[1][2].
Name	CP 122721 hydrochloride
CAS	145877-52-7
Formula	C20H25Cl2F3N2O2
Molar Mass	453.33
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. McLean S, et, al. Characterization of CP-122,721; a nonpeptide antagonist of the neurokinin NK1 receptor. J Pharmacol Exp Ther. 1996 May;277(2):900-8. [2]. Kamel A, et, al. Metabolism and excretion of CP-122,721, a non-peptide antagonist of the neurokinin NK1 receptor, in dogs: identification of the novel cleaved product 5-trifluoromethoxy salicylic acid in plasma. Xenobiotica. 2007 May;37(5):559-78.

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