| Bioactivity | COX-2/LOX-IN-2 (compound 6) is a dual inhibitor of COX-2/LOX with IC50s of 7.0 μM and 27.5 μM, respectively. COX-2/LOX-IN-2 has antioxidant activity and has the potential to be used in the development of nonsteroidal anti-inflammatory drugs (tNSAIDs)[1]. |
| Target | 7.0 μM (COX-2), 27.5 μM (Lipoxygenase, LOX) |
| Name | COX-2/LOX-IN-2 |
| Formula | C28H23ClN2O2 |
| Molar Mass | 454.95 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Noti V, et al. Development of Novel Pyrrole Derivatives and Their Cinnamic Hybrids as Dual COX-2/LOX Inhibitors. Molecules. 2023 Dec 5;28(24):7958. |