| Bioactivity | COX-2-IN-44 is a potent and orally active COX-2 inhibitor with IC50 values of 0.18,1.14 µM for COX-2, COX-1, respectively. COX-2-IN-44 shows anti-inflammatory activity[1]. |
| In Vivo | COX-2-IN-44 (compound 6b) (10 mg/kg; p.o.) 在大鼠中表现出抗炎活性[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| Formula | C27H24ClN3O |
| Molar Mass | 441.95 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ewieda SY, et al. Synthesis, COX-2 inhibition, anti-inflammatory activity, molecular docking, and histopathological studies of new pyridazine derivatives. Bioorg Chem. 2024 Sep;150:107623. |