COX-2-IN-24

CAS: 2417995-10-7 F: C24H24BrN5O3S2 W: 574.51

COX-2-IN-24 is an orally active inhibitor of COX-2 with IC50 value of 0.17 μM, shows anti-inflammatory and low ulceroge

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Bioactivity	COX-2-IN-24 is an orally active inhibitor of COX-2 with IC50 value of 0.17 μM, shows anti-inflammatory and low ulcerogenic activities.
In Vivo	COX-2-IN-24 (Intraperitoneal injection; 9mg/100g; once an hour; 4 hours) shows anti-inflammatory activity in the carrageenan-induced rat paw edema model[1].COX-2-IN-24 (Oral gavage; 9mg/100g; once a day; 3 days) shows low ulcerogenic activity in the received 1% gum acacia (suspending vehicle) orally male albino rats model [1]. Animal Model:
Name	COX-2-IN-24
CAS	2417995-10-7
Formula	C24H24BrN5O3S2
Molar Mass	574.51
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Tarek S Ibrahim, et al. Design, synthesis, and pharmacological evaluation of novel and selective COX-2 inhibitors based on bumetanide scaffold. Bioorg Chem. 2020 Jul;100:103878.

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