Bioactivity | 7,3',4'-Trihydroxy-3-benzyl-2H-chromene is an reversible noncompetitive neuraminidase (NA) inhibitor. 7,3',4'-Trihydroxy-3-benzyl-2H-chromene can be isolated from the dried heartwood of Caesalpinia sappan L. 7,3',4'-Trihydroxy-3-benzyl-2H-chromene has potent NAs inhibitory activities with IC50 values of 34.6 µM [H1N1], 39.5 µM [H3N2], and 50.5µM [H9N2], respectively. 7,3',4'-Trihydroxy-3-benzyl-2H-chromene can be used for the research of influenza virus[1][2]. |
Target | IC50: 34.6 µM , 39.5 µM , and 50.5 µM . |
Invitro | 7,3',4'-Trihydroxy-3-benzyl-2H-chromene 具有有效的 NAs 抑制活性,IC50 值分别为 34.6 µM [H1N1]、39.5 µM [ H3N2] 和 50.5 µM [H9N2][1]。 |
Name | 7,3',4'-Trihydroxy-3-benzyl-2H-chromene |
CAS | 1111897-60-9 |
Formula | C16H14O4 |
Molar Mass | 270.28 |
Transport | Room temperature in continental US; may vary elsewhere. |
Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Reference | [1]. Hyung Jae Jeong, et al. Homoisoflavonoids from Caesalpinia sappan displaying viral neuraminidases inhibition. Biol Pharm Bull. 2012;35(5):786-90. [2]. Huanxin Zhao, et al. A new homoisoflavan from Caesalpinia sappan. J Nat Med. 2008 Jul;62(3):325-7. |