| Bioactivity | COX-1/2-IN-8 (compound 11f) is an orally active and potent inhibitor of COX-1 and COX-2, with IC50 values of 2.14 and 0.58 µM, respectively. COX-1/2-IN-8 displays a higher significant anti-inflammatory activity than Celecoxib (HY-14398)[1]. |
| In Vivo | COX-1/2-IN-8 (compound 11f) (50 mg/kg, 口服) 在大鼠中表现出抗炎活性[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| Formula | C33H30N4OS |
| Molar Mass | 530.68 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Abo-Elmagd MI, et al. Design, synthesis and anti-inflammatory assessment of certain substituted 1,2,4-triazoles bearing tetrahydroisoquinoline scaffold as COX 1/2-inhibitors. Bioorg Chem. 2024 Sep;150:107577. |