| Bioactivity | COE-PNH2 exhibits antibacterial activity against Mycobacterium abscessus (Mab) with MIC90 of 26 μM. COE-PNH2 affects the integrity of the bacterial envelope and mycomembrane. COE-PNH2 reveals intracelluar penetration without mitochondrial toxicity[1]. |
| Invitro | COE-PNH2 (0-128 μg/mL) 对细胞内的，复制型和营养匮乏的 Mab 表现出稳定的抗菌活性和极高的抗生素耐受性[1]。COE-PNH2 表现出较低的耐药性发展倾向，并且在 14 次连续传代的 Mab 中具有一致的 MIC 值[1]。COE-PNH2 (0-64 μg/mL) 诱导 Mab 中 ATP 消耗，细胞内脂质包涵体 (ILIs) 累积和细菌伸长[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> COE-PNH2 相关抗体: |
| In Vivo | COE-PNH2 (2.5-5 mg/kg，气管内给药，每两天一次共 12 天) 在急性肺部感染的 C3HeB/FeJ 小鼠体内展现出良好的耐受性和有效性[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| Formula | C54H98Cl8N8O4 |
| Molar Mass | 1207.03 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zhang K, et al., An anti-mycobacterial conjugated oligoelectrolyte effective against Mycobacterium abscessus. Sci Transl Med. 2024 Feb 21;16(735):eadi7558. |