Cantharidic acid disodium

CAS: 1465-77-6 F: C10H12Na2O5 W: 258.18

Cantharidic acid disodium is the hydrolysis product of the acid anhydride Cantharidin that induces apoptosis in various

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Bioactivity	Cantharidic acid disodium is the hydrolysis product of the acid anhydride Cantharidin that induces apoptosis in various human cancer cells. Cantharidic acid disodium is a selective protein phosphatase 2 (PP2A) and PP1 inhibitor withIC50 values of 50 nM and 600 nM, respectively[1][2].
Invitro	Cantharidic acid（0-20 μM；24 小时）显着降低细胞活力，这是通过外源性和内源性细胞凋亡途径中 caspase 激活的上调以及 ERK1/2、p38 和 JNK1/2 途径的上调来揭示的[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Cantharidic acid disodium 相关抗体: Cell Viability Assay[1] Cell Line:
In Vivo	Cantharidic acid（10 mg/kg；腹腔注射；一次）会导致小鼠肝脏极度肿大和充血。血糖和肝糖原磷酸化酶水平升高以及肝糖原含量和糖原合成酶活性相应降低可以证明肝糖原分解增加[3]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.
CAS	1465-77-6
Formula	C10H12Na2O5
Molar Mass	258.18
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Yi-Ching Chen, et al. Cantharidic acid induces apoptosis in human nasopharyngeal carcinoma cells through p38-mediated upregulation of caspase activation. Environ Toxicol. 2020 May;35(5):619-627. [2]. Adam McCluskey, et al. Serine-threonine protein phosphatase inhibitors: development of potential therapeutic strategies. J Med Chem. 2002 Mar 14;45(6):1151-75. [3]. M J Graziano, et al. Comparison of the acute toxicity of endothal and cantharidic acid on mouse liver in vivo. Toxicol Lett. 1987 Jul;37(2):143-8.