| Bioactivity | CL075 (3M002) is a selective TLR8 agonist with immunomodulating properties. CL075 triggers a MyD88-dependent signaling pathway to elicit production of inflammatory cytokines and type I interferons (IFNs) via activation of NF-κB and IRF7, respectively[1][2][3]. | ||||||||||||
| Invitro | CL075 (2 μM; 4 h) induces the production of IL-6, IL-8, and IFN-γ in rabbit splenocytes[1].CL075 (2 μM; 48 h) induces the total IgM production and cell proliferation in rabbit splenocytes[1].CL075 (2 μM; 7 h) activates the rabTLR8 in 293 cells[1]. | ||||||||||||
| In Vivo | CL075 (5 μM (0.5 mL); s.c.) activates a mild antigen-specific antibody response in rabbits[1]. | ||||||||||||
| Name | CL075 | ||||||||||||
| CAS | 256922-53-9 | ||||||||||||
| Formula | C13H13N3S | ||||||||||||
| Molar Mass | 243.33 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Lai CY, et, al. TLR7/8 agonists activate a mild immune response in rabbits through TLR8 but not TLR7. Vaccine. 2014 Sep 29;32(43):5593-9. [2]. Spranger S, et, al. Generation of Th1-polarizing dendritic cells using the TLR7/8 agonist CL075. J Immunol. 2010 Jul 1;185(1):738-47. [3]. Maalej KM, et, al. TLR8, but not TLR7, induces the priming of the NADPH oxidase activation in human neutrophils. J Leukoc Biol. 2015 Jun;97(6):1081-7. |