| Bioactivity | CL-242817 is an orally available angiotensin converting enzyme (ACE) inhibitor. CL-242817 inhibits the conversion of angiotensin I to angiotensin II and has blood pressure lowering activity. CL-242817 can also improve Monocrotaline (HY-N0750) induced lung injury. CL-242817 can be used in the study of pulmonary fibrosis and hypertension-related diseases[1]. |
| In Vivo | CL-242817 (60 mg/kg, p.o., 每天一次, 持续六周) 给药的雄性 Wistar 大鼠未能以正常速度增重且心脏功能降低，显著改善了 Monocrotaline (HY-N0750) 造成的血管闭塞和单胆碱损伤，并抑制 ACE 活性和降低肺中羟脯氨酸 (HP) 含量[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| CAS | 86709-48-0 |
| Formula | C18H21NO5S |
| Molar Mass | 363.43 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Molteni et al. Monocrotaline-induced cardiopulmonary damage in rats: amelioration by the angiotensin-converting enzyme inhibitor CL242817. Proceedings of the Society for Experimental Biology and Medicine 182.4 (1986): 483-493. |