| Bioactivity | CGP36216 hydrochloride is a selective antagonist at GABA presynaptic receptor. CGP36216 binds to GABAB receptor with a Ki value of 0.3 μM. CGP36216 hydrochloride can be used for research of anxiety and trauma-related disorders[1][2]. |
| Invitro | CGP36216 对 GABA 突触后受体无效，但在突触前受体上更为活跃。CGP36216 (100 µM)可以增加 VTA-DA 神经元自发放电的频率。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> CGP36216 hydrochloride 相关抗体: |
| In Vivo | Animal Model: |
| CAS | 1781834-71-6 |
| Formula | C5H15ClNO2P |
| Molar Mass | 187.60 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. William Howson, et al. Biological activity of 3-aminopropyl (methyl) phosphinic acid, a potent and selective GABAB agonist with CNS activity. Bioorganic & Medicinal Chemistry Letters. Volume 3, Issue 4, April 1993, Pages 515-518. [2]. J Ong, et al. CGP 36216 is a selective antagonist at GABA(B) presynaptic receptors in rat brain. Eur J Pharmacol. 2001 Mar;415(2-3):191-5. [3]. Ming Chen, et al. Morphine disinhibits glutamatergic input to VTA dopamine neurons and promotes dopamine neuron excitation. Elife. 2015 Jul 24:4:e09275. |
CGP36216 hydrochloride
CAS: 1781834-71-6 F: C5H15ClNO2P W: 187.60
CGP36216 hydrochloride is a selective antagonist at GABA presynaptic receptor. CGP36216 binds to GABAB receptor with a K
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