| Bioactivity | CDKL5/GSK3-IN-1 (Compound 2) is a potent and selectivity chemical probe for CDKL5/GSK3.CDKL5/GSK3-IN-1 has potent inhibition of CDKL5 and GSK3α/β, with IC50 values of 4.6, 24 and 9.5 nM for CDKL5, GSK3β and GSK3α, respectively, in the NanoBRET assay. CDKL5/GSK3-IN-1 can be used for the research of CNS diseases[1]. |
| CAS | 844442-32-6 |
| Formula | C16H17F2N5O2 |
| Molar Mass | 349.34 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ong HW, et al. A Potent and Selective CDKL5/GSK3 Chemical Probe is Neuroprotective. bioRxiv [Preprint]. 2023 Feb 10:2023.02.09.527935. |
CDKL5/GSK3-IN-1
CAS: 844442-32-6 F: C16H17F2N5O2 W: 349.34
CDKL5/GSK3-IN-1 (Compound 2) is a potent and selectivity chemical probe for CDKL5/GSK3.CDKL5/GSK3-IN-1 has potent inhibi
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