| Bioactivity | CDK7-IN-27 (Compound 37) is a selective inhibitor for cyclin-dependent kinase 7 (CDK7), with Ki of 3 nM. CDK7-IN-27 arrests the cell cycle at G0/G1 phase[1]. |
| Invitro | CDK7-IN-27 (0.04-10 μM, 5 days) 抑制 MDA-MB-453 细胞增殖，EC50 为 1.49 μM[1]。CDK7_IN-27 (1 μM, 24 h) 在小鼠和人的肝微粒体中表现出良好的代谢稳定性，半衰期分别为 38.5 分钟和 34.1 分钟[1]。CDK7_IN-27 (0-1 μM, 24 h) 通过抑制 CDK7 抑制视网膜母细胞瘤蛋白的磷酸化，从而将细胞周期阻滞在 G0/G1 期[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> CDK7-IN-27 相关抗体: Western Blot Analysis[1] Cell Line: |
| Formula | C26H37N7O2 |
| Molar Mass | 479.62 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Niu P, et al., Design and Synthesis of Novel Macrocyclic Derivatives as Potent and Selective Cyclin-Dependent Kinase 7 Inhibitors. J Med Chem. 2024 Apr 8. |