| Bioactivity | CCK-B Receptor Antagonist 2, compound 15b, is a potent and orally active Gastrin/CCK-B antagonist with an IC50 value of 0.43 nM. CCK-B Receptor Antagonist 2 also inhibits gastrin/CCK-A activity with an IC50 of 1.82 μM[1]. | ||||||||||||
| Target | IC50: 0.43 nM (Gastrin/CCK-B); 1.82 μM (Gastrin/CCK-A) | ||||||||||||
| In Vivo | CCK-B Receptor Antagonist 2 (0.1 μmol/kg; intravenous injection) has an inhibition effect on pentagastrin-induced gastric acid secretion in anethsetized rats with an ED50 of 8.3 nmol/kg[1]. | ||||||||||||
| Name | CCK-B Receptor Antagonist 2 | ||||||||||||
| CAS | 155412-88-7 | ||||||||||||
| Formula | C27H28N6O3 | ||||||||||||
| Molar Mass | 484.55 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
|
||||||||||||
| Reference | [1]. Semple G, et al. (3R)-N-(1-(tert-butylcarbonylmethyl)-2,3-dihydro-2-oxo-5-(2-pyridyl)-1H-1,4-benzodiazepin-3-yl)-N'-(3-(methylamino)phenyl)urea (YF476): a potent and orally active gastrin/CCK-B antagonist.J Med Chem. 1997 Jan 31;40(3):331-41. |
CCK-B Receptor Antagonist 2
CAS: 155412-88-7 F: C27H28N6O3 W: 484.55
CCK-B Receptor Antagonist 2, compound 15b, is a potent and orally active Gastrin/CCK-B antagonist with an IC50 value of
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.