| Bioactivity | CB2R-IN-3 is a selective antagonist of cannabinoid type 2 receptor (CB2R). CB2R-IN-3 has high affinity for human CB2R and specific selectivity for CB1R. CB2R-IN-3 can be combined with CB65 (HY-110047), the activator of CB2R. CB2R-IN-3 effectively up-regulates the expression of anti-inflammatory cytokines and down-regulates the expression of pro-inflammatory cytokines[1]. |
| Invitro | CB2R-IN-3 (compound 10a) (1 和 10 µM；24 h) 与激活剂 CB65 联用时，在脂多糖存在下，显著降低了 TNF-α、IFN-γ、IL-1β、IL-6 促炎细胞因子的表达，增加了 IL-10 抗炎细胞因子的表达[1]。 |
| Name | CB2R-IN-3 |
| Formula | C27H42N2O |
| Molar Mass | 410.64 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Graziano G, et al. N-adamantyl-anthranil amide derivatives: New selective ligands for the cannabinoid receptor subtype 2 (CB2R). Eur J Med Chem. 2023 Feb 15;248:115109. |