| Bioactivity | Antroquinonol ((+)-Antroquinonol), a ubiquinone derivative from the mushroom Antrodia camphorata, has hepatoprotective, anti-inflammatory, and anti-cancer effects[1]. Antroquinonol can be used for the research of colon cancer[2]. Antroquinonol reduces oxidative stress by enhancing the Nrf2 signaling pathway and inhibits inflammation and sclerosis in focal segmental glomerulosclerosis mice[3]. |
| Invitro | Antroquinonol is a ubiquinone derivative from A.camphorata[2]. Antroquinonol inhibits cell growth and suppresses the migratory/invasive ability of human colon cancer cells. Antroquinonol at high concentrations (40-80 μM) exhibits growth inhibitory activities in the three colon cancer cell lines, whereas low concentrations of Antroquinonol (2.5-20 μM) shows modest growth inhibition[2]. Antroquinonol possesses the ability to inhibit breast cancer migration/invasion by inhibiting the EMT and MMP-9 gene expression[2].Antroquinonol has inducible nitric oxide synthase (iNOS) inhibitory activity in lipopolysaccharide (LPS)-activated macrophages, anti-inflammatory activity in macrophage cell cultures by reducing the production of tumor necrosis factor-α and interleukin (IL)-1β, and anti-cancer activity against hepatoma cells[3]. Cell Viability Assay[2] Cell Line: |
| In Vivo | Antroquinonol is a major active component of a mushroom, namely Antrodia camphorate, and it has inhibitory effects on nitric oxide production and inflammatory reactions.Antroq ameliorates proteinuria, improves renal function, and decreases renal lesions, including EPHL, a severe index of glomerular injury, in FSGS mice[3]. Animal Model: |
| Name | Antroquinonol |
| CAS | 1010081-09-0 |
| Formula | C24H38O4 |
| Molar Mass | 390.56 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zhen-Wei Yi, et al. Antrodin A from mycelium of Antrodia camphorata alleviates acute alcoholic liver injury and modulates intestinal flora dysbiosis in mice. J Ethnopharmacol. 2020 May 23;254:112681. [2]. Hsien-Chun Lin, et al. Antroquinonol, a Ubiquinone Derivative from the Mushroom Antrodia camphorata, Inhibits Colon Cancer Stem Cell-like Properties: Insights into the Molecular Mechanism and Inhibitory Targets. J Agric Food Chem.2017 Jan 11;65(1):51-59. [3]. Pei-Yi Tsai, et al. Antroquinonol reduces oxidative stress by enhancing the Nrf2 signaling pathway and inhibits inflammation and sclerosis in focal segmental glomerulosclerosis mice. Free Radic Biol Med. 2011 Jun 1;50(11):1503-16. |
Antroquinonol
CAS: 1010081-09-0 F: C24H38O4 W: 390.56
Antroquinonol ((+)-Antroquinonol), a ubiquinone derivative from the mushroom Antrodia camphorata, has hepatoprotective,
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