| Bioactivity | CAY10410 (11-Oxo-prosta-5Z), a 15d-PGJ2 analog, is a potent PPARγ agonist. CAY10410 has the ability to activate PPARγ in human B cells without killing B lymphocytes[1]. |
| Invitro | Cay10410 (11-Oxo-prosta-5Z; 1 μM; 24 h) 激活 PPRE-LUC 活性，该激活被 B细胞中的 PPARγ DN 抑制[1]。Cay10410 (0-25 μM; 48 h) 对 Ramos 细胞或正常人 B 细胞均无抑制作用，即使剂量高达 25 μM[1]。 |
| Name | CAY10410 |
| CAS | 596104-94-8 |
| Formula | C20H30O3 |
| Molar Mass | 318.45 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ray DM, et, al. The peroxisome proliferator-activated receptor gamma (PPARgamma) ligands 15-deoxy-Delta12,14-prostaglandin J2 and ciglitazone induce human B lymphocyte and B cell lymphoma apoptosis by PPARgamma-independent mechanisms. J Immunol. 2006 Oct 15;177(8):5068-76. |