| Bioactivity | Bismuth Subsalicylate is a potent and orally active antacid and anti-diarrheal agent. Bismuth Subsalicylate reduces inflammation/irritation of stomach and intestinal lining through inhibition of prostaglandin synthesis in vivo[1]. Bismuth Subsalicylate is widely used for the research of diarrheal disorders, including indigestion, diarrhoea, nausea, et al[1][2]. | ||||||||||||
| In Vivo | In the gastrointestinal tract, Bismuth Subsalicylate can be converted to salicylic acid and insoluble bismuth salts. Salicylic acid reduces inflammation/irritation of stomach and intestinal lining through inhibition of prostaglandin G/H synthase 1/2[1].Bismuth Subsalicylate (oral gavage; 100 mg/kg-350 mg/kg) significantly decreases castor oil-induced movement of a charcoal test meal along the small intestine of the mouse and rat and also decreases both the fecal output (dry or wet weight) and the frequency of diarrhea in mice[2]. | ||||||||||||
| Name | Bismuth Subsalicylate | ||||||||||||
| CAS | 14882-18-9 | ||||||||||||
| Formula | C7H5BiO4 | ||||||||||||
| Molar Mass | 362.09 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
|
||||||||||||
| Reference | [1]. Bismuth subsalicylate. Drug.bank [2]. Alejandra Orona-Ortiz, et al. Mucoadhesive effect of Curcuma longa extract and curcumin decreases the ranitidine effect, but not bismuth subsalicylate on ethanol-induced ulcer model. Sci Rep. 2019 Nov 12;9(1):16622. |
Bismuth Subsalicylate
CAS: 14882-18-9 F: C7H5BiO4 W: 362.09
Bismuth Subsalicylate is a potent and orally active antacid and anti-diarrheal agent. Bismuth Subsalicylate reduces infl
Data collection：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.