| Bioactivity | Biotin-YVAD-FMK is an inhibitor for vacuolar processing enzyme (VPE), with a 64% inhibition at 5 μM. Biotin-YVAD-FMK is an irreversible substrate for caspase 1[1][2]. |
| Sequence | Biotin-Tyr-Val-Ala-Asp-FMK |
| Shortening | Biotin-YVAD-FMK |
| Formula | C32H45FN6O9S |
| Molar Mass | 708.80 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Hatsugai N, et al., A plant vacuolar protease, VPE, mediates virus-induced hypersensitive cell death. Science. 2004 Aug 6;305(5685):855-8. [2]. Case CL, et al., Asc modulates the function of NLRC4 in response to infection of macrophages by Legionella pneumophila. mBio. 2011 Sep 1;2(4):e00117-11. |