| Bioactivity | Antitumor agent-150 (V10), an anti-breast cancer agent, is a PROTAC-based MDM2 protein degrader (Red: Ganoderic acid A; Black: 4O-PEG linker; Blue: VHL ligand)[1]. |
| Invitro | Antitumor agent-150 (V10) 在 TNBC 斑马鱼模型中表现出良好的抑瘤活性，50 μg/mL 的抑制率为 27.2%[1]。Antitumor agent-150 (V10, 10 μM) 促进 MDA-MB-231 细胞的凋亡[1]。Antitumor agent-150 (V10) 处理显著改变MDA-MB-231细胞的 G1 期和 S 期[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Antitumor agent-150 相关抗体: |
| Formula | C70H106N8O14S |
| Molar Mass | 1315.70 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Yan Li, et al. Discovery of ganoderic acid A (GAA) PROTACs as MDM2 protein degraders for the treatment of breast cancer. Eur J Med Chem. 2024 Apr 15:270:116367. |
Antitumor agent-150
CAS: F: C70H106N8O14S W: 1315.70
Antitumor agent-150 (V10), an anti-breast cancer agent, is a PROTAC-based MDM2 protein degrader (Red: Ganoderic acid A;
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This product is for research use only, not for human use. We do not sell to patients.