| Bioactivity | Balanophonin is an anti-inflammatory and anti-cancer agent. Balanophonin inhibits microglial activation and neurodegeneration via inhibiting activated microglia-induced apoptosis[1]. |
| Invitro | Balanophonin (1-10 μM; 24 h) 在 BV2 细胞中降低 Lipopolysaccharides (LPS; HY-D1056) 介导的 TLR4 激活和 NO 生成[1]。Balanophonin (1-10 μM; 6 h) 降低 LPS 诱导的小胶质细胞中 iNOS 和 COX2 蛋白的表达以及 TNF-α 和 IL-1β 的产生[1]。Balanophonin (1-10 μM; 30 min) 有效抑制 MAPK 激活[1]。 Balanophonin (1-10 μM; 24 h) 通过调节 N2a 细胞中裂解的 caspase-3 和聚 ADP 核糖聚合酶 (PARP) 的裂解,抑制 LPS 激活的小胶质细胞引起的神经元细胞死亡[1]。 Western Blot Analysis[1] Cell Line: |
| Name | Balanophonin |
| CAS | 80286-36-8 |
| Formula | C20H20O6 |
| Molar Mass | 356.37 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |