BTK-IN-18

CAS: 1374239-71-0 F: C20H22Cl2N6O W: 433.33

BTK-IN-18 is a potent, reversible BTK inhibitor with an IC50 of 0.002 µM. BTK-IN-18 inhibits both CD69 and CD86 in vivo

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Bioactivity	BTK-IN-18 is a potent, reversible BTK inhibitor with an IC50 of 0.002 µM. BTK-IN-18 inhibits both CD69 and CD86 in vivo[1].
In Vivo	BTK-IN-18 (化合物 41; 10, 25, 45 mg/kg; 腹腔给药; 单剂量) 对 CD69 和 CD86 产生强烈的剂量依赖性抑制[1]。 BTK-IN-18 (静脉给药; 1 mg/kg) 在大鼠中的 T1/2 为 5.3 小时，CL 为 19 mL/min/kg，Vss 为 1.3 L/kg[1]。 Animal Model:
Name	BTK-IN-18
CAS	1374239-71-0
Formula	C20H22Cl2N6O
Molar Mass	433.33
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. George H Vandeveer, et al. Discovery of structural diverse reversible BTK inhibitors utilized to develop a novel in vivo CD69 and CD86 PK/PD mouse model. Bioorg Med Chem Lett. 2022 Dec 17;80:129108.