| Bioactivity | BRD7-IN-2 (compound 2-77) is a potent inhibitor of bromodomain-containing protein 7 (BRD7), targeting to prostate cancer cells. BRD7-IN-2 is selective for BRD7 rather than BRD9, with IC50s of 5.4 μM, and >300 μM, respectively. |
| Target | IC50: 5.4 μM (BRD7); Ki: 1.3 μM (BRD7) |
| Invitro | BRD7-IN-2 (compound 2-77) 在 HEK293T 细胞中对 BRD7 和 BRD9 有抑制作用，IC50 分别为 1.1 μM 和 3.2 μM[1]。 0 --> BRD7-IN-2 相关抗体: |
| Name | BRD7-IN-2 |
| Formula | C18H18N2O3 |
| Molar Mass | 310.35 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ordonez-Rubiano SC, Maschinot CA, Wang S, Sood S, Baracaldo-Lancheros LF, Strohmier BP, McQuade AJ, Smith BC, Dykhuizen EC. Rational Design and Development of Selective BRD7 Bromodomain Inhibitors and Their Activity in Prostate Cancer. J Med Chem. 2023 Aug 24;66(16):11250-11270. |