BChE/HDAC6-IN-2_product_DataBase

Bioactivity	BChE/HDAC6-IN-2 (compound 29a) is a dual inhibitor of BChE and HDAC6 with IC50s of 1.8 nM and 71.0 nM, respectively. BChE/HDAC6-IN-2 has prominently neuroprotective effects and reactive oxygen species (ROS) scavenging activity. BChE/HDAC6-IN-2 is also an effective chelator of metal ion (Fe2+ and Cu2+). BChE/HDAC6-IN-2 inhibits phosphorylation of tau, and exhibits moderate immunomodulatory effect.
Target	IC50: 1.8 nM (BChE), 71.0 nM (HDAC6)
Invitro	BChE/HDAC6-IN-2 (compound 29a) (0.1 μM，1 μM；24 小时) 在 10 μM Aβ(1-42) 处理的 SH-SY5Y 细胞中增加 α-微管蛋白的乙酰化水平，抑制 tau 的磷酸化[1]。BChE/HDAC6-IN-2 (5 μM、10 μM、20 μM) 抑制 SH-SY5Y 细胞中谷氨酸诱导的损伤，显示出神经保护作用[1]。 0 --> BChE/HDAC6-IN-2 相关抗体:
Name	BChE/HDAC6-IN-2
CAS	2925457-33-4
Formula	C27H30N4O4
Molar Mass	474.55
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Wang L, Sun T, Wang Z, Liu H, Qiu W, Tang X, Guo H, Yang P, Chen Y, Sun H. Design, Synthesis, and Proof of Concept of Balanced Dual Inhibitors of Butyrylcholinesterase (BChE) and Histone Deacetylase 6 (HDAC6) for the Treatment of Alzheimer's Disease. ACS Chem Neurosci. 2023 Sep 6;14(17):3226-3248.

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