| Bioactivity | BRD4 Inhibitor-38 (Compound 25) is an orally active inhibitor of BRD4 with IC50 values of 3.64 μM and 0.12 μM against BRD4 BD1 and BRD4 BD2, respectively. BRD4 Inhibitor-38 also exhibits anti-inflammatory activity, with an IC50 value of 1.98 μM for inhibiting nitric oxide (NO) production[1]. |
| Invitro | BRD4 Inhibitor-38 (Compound 25) (2.5-20 μM; 2 h) 在 Raw 264.7 和 THP-1 细胞中具有抗炎活性[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> BRD4 Inhibitor-38 相关抗体: Real Time qPCR[1] Cell Line: |
| In Vivo | BRD4 Inhibitor-38 (Compound 25) (25-100 mg/kg; p.o.; 单剂量) 在 LPS (10mg/kg; Single dose) (HY-D1056) 诱导的急性炎症小鼠模型中具有抗炎活性[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| Formula | C19H18N2O4 |
| Molar Mass | 338.36 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Chen S, et al. Marine natural product-inspired discovery of novel BRD4 inhibitors with anti-inflammatory activity[J]. European Journal of Medicinal Chemistry, 2024: 117193. |